Mutational effects on carbapenem hydrolysis of YEM-1, a new sub-class B2 metallo-β-lactamase from Yersinia mollaretii
P. S. Mercuri, R. Esposito, S. Bletard, S. Di Costanzo, M. G. Perilli, F. Kerff, M. Galleni
The paper characterizes YEM-1, a new subclass B2 metallo-β-lactamase from Yersinia mollaretii, showing it hydrolyzes only imipenem efficiently and identifies key residues responsible for its substrate specificity.
bioRxiv · Jan 29, 2020Biochemistry