F. Kerff

The Arabidopsis SR45 splicing factor bridges the splicing machinery and the exon-exon junction complex

This study examines the role of individual domains in the Arabidopsis SR45 splicing factor, showing its nuclear localization, RNA binding specificity, and interaction with spliceosome and EJC components.

Common scab disease: structural basis of elicitor recognition in pathogenic Streptomyces species

This paper solves the structure of CebE from Streptomyces scabiei bound to cellotriose, revealing its role in pathogenicity and conserved signaling pathways in common scab-causing species.

Origin and Evolution of Pseudomurein Biosynthetic Gene Clusters

This study identifies and characterizes pseudomurein biosynthetic genes in Archaea, showing their bacterial origin and evolutionary diversification through horizontal gene transfer and duplication.

Development of nanobodies as theranostic agents against CMY-2-like class C β-lactamases

This study identifies VHH nanobodies that inhibit CMY-2 class C β-lactamases and develops an ELISA for detecting these enzymes in resistant bacteria.

Structure and function of BcpE2, the most promiscuous GH3-family beta-glucosidase for scavenging glucose from heterosides

This study identifies BcpE2 as a highly promiscuous GH3-family beta-glucosidase in Streptomyces scabiei that hydrolyzes diverse plant-derived heterosides, enabling glucose scavenging and virulence modulation.

An extended reservoir of class-D beta-lactamases in non-clinical bacterial strains

The paper identifies new class-D beta-lactamases in environmental bacteria, showing their potential to hydrolyze carbapenems and contribute to antibiotic resistance.

Biochemical and structural insights into the activation of PBP1b by the essential domain of FtsN

This study identifies EFtsN as a specific activator of PBP1b, showing it binds to PBP1b and enhances its GTase activity, with structural insights into their interaction.

Mutational effects on carbapenem hydrolysis of YEM-1, a new sub-class B2 metallo-β-lactamase from Yersinia mollaretii

The paper characterizes YEM-1, a new subclass B2 metallo-β-lactamase from Yersinia mollaretii, showing it hydrolyzes only imipenem efficiently and identifies key residues responsible for its substrate specificity.