Computer Simulations of the Humoral Immune System Reveal How Imprinting Can Affect Responses to Influenza HA Stalk with Implications for the Design of Universal Vaccines
C. S. Anderson, M. Y. Sangster, H. Yang, S. Chaudhury, D. J. Topham
The paper uses computer simulations to show that prior exposure to antigenically dissimilar strains can enhance cross-reactive antibody responses to conserved influenza HA regions, with implications for universal vaccine design.
bioRxiv · Feb 15, 2019 · PreprintImmunology