HnRNP C binding to inverted Alu elements protects the transcriptome from pre-mRNA circularization
Alberto Marini, Consuelo Pitolli, S. Ciccone, Marco Pieraccioli, Noémie Robil, Chiara Naro, Fernando Palluzzi, Manuela Giansanti, Gianpiero Tamburrini, Luciano Giacò, Pierre de la Grange, Francesca Nazio, Pamela Bielli, Claudio Sette, Vittoria Pagliarini
This study identifies hnRNP C as a repressor of circRNA biogenesis in Group 3 medulloblastoma by binding Alu elements and preventing pre-mRNA circularization.
Science Advances · May 1, 2026Peer-reviewedCancer Biology