Sotagliflozin, a dual SGLT1/2 inhibitor, improves cardiac outcomes in a mouse model of early heart failure without diabetes
S. L. Young, L. Ryan, T. P. Mullins, M. Flint, S. E. Steane, S. L. Walton, H. Bielefeldt-Ohmann, D. A. Carter, M. E. Reichelt, L. A. Gallo
This study shows that sotagliflozin, a dual SGLT1/2 inhibitor, improves cardiac outcomes in non-diabetic mice with heart failure but not in diabetic mice with proximal tubular damage.
bioRxiv · Aug 15, 2020 · PreprintPharmacology & Toxicology