Pseudogene-mediated gene conversion after CRISPR-Cas9 editing demonstrated by partial CD33 conversion with SIGLEC22P
The paper demonstrates that CRISPR-Cas9 editing can lead to pseudogene-mediated gene conversion, resulting in unexpected missense mutations in CD33 through homology repair with the SIGLEC22P pseudogene.
bioRxiv · Apr 20, 2021Cell Biology