Mutants libraries reveal negative design shielding proteins from mis-assembly and re-localization in cells
H. Garcia-Seisdedos, T. Levin, G. Shapira, S. Freud, E. D. Levy
The paper shows that surface mutations in homo-oligomeric proteins often cause mislocalization and misassembly, revealing negative design that shields against these effects.
bioRxiv · Jan 20, 2021Biophysics