The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brain
S. Fruhwurth, L. Reinert, C. Oberg, M. Sakr, M. Henricsson, H. Zetterberg, S. Paludan
This study shows that TREM2 is critical for microglial antiviral responses against HSV1, enhancing IFN-I production and phagocytosis, and its loss increases susceptibility to infection.
bioRxiv · Mar 16, 2023 · PreprintImmunology