Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis
T. Gonzalez-Munoz, A. Di Giannatale, S. Garcia-Silva, V. Santos, S. Sanchez-Redondo, C. Savini, O. Grana-Castro, C. Blanco, D. J. Pisapia, J. L. Peralto, C. Romagosa Perez-Portabella, R. Alaggio, M. S. Benassi, L. Pazzaglia, K. Scotlandi, , H. Peinado
This study identifies endoglin (ENG) as a biomarker and therapeutic target for MPNSTs, showing that targeting ENG with antibodies or combining it with MEK inhibitors reduces tumor growth and metastasis.
Clinical Cancer Research · Jul 11, 2023Peer-reviewedCancer Biology