Downregulation of the secreted protein with an altered thrombospondin repeat (SPATR) impacts the infectivity of malaria sporozoites
D. M. Costa, M. Sa, A. R. Teixeira, B. Perez-Cabezas, S. Golba, H. Sefiane-Djemaoune, P. Formaglio, B. Franke-Fayard, C. J. Janse, R. Amino, J. Tavares
This study shows that downregulating SPATR in malaria sporozoites impairs their motility, salivary gland invasion, and infectivity to mice.
bioRxiv · Mar 6, 2022 · PreprintMicrobiology