Structural Insights into The Role of MAGEA4 in RAD18 Regulation: Implications for Ubiquitin Ligase-Binding across the MAGE Protein Family
S. Griffith-Jones, L. Alvarez, U. Mukhopadhyay, S. Gharbi, M. Rettel, M. Adams, J. Hennig, S. Bhogaraju
This study identifies the interaction between MAGEA4 and RAD18 using NMR and AlphaFold2, revealing structural insights into how MAGEA4 regulates RAD18's ubiquitination activity and its implications for cancer.
bioRxiv · Dec 8, 2023 · PreprintBiochemistry