Comprehensive genome editing confers "off-the-shelf" CAR-T cells superior efficacy against solid tumors
R. Murray, N. R. R. Navarrete, K. Desai, M. R. Chowdhury, S. R. Chilakapati, B. Chong, A. Messana, H. Sobon, J. Rocha, F. Musenge, A. Camblin, G. Ciaramella, M. Sitkovsky, C. Maldini, S. Hatfield
The paper develops genome-edited CAR-T cells resistant to multiple inhibitory signals, showing improved efficacy against solid tumors in humanized mouse models.
bioRxiv · Aug 3, 2023 · PreprintCell Biology