Author

S. J. Jacobi

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Kuenkele· 1 shared B. L. Cadilha· 1 shared B. Popper· 1 shared D. Anz· 1 shared D. Matzek· 1 shared F. Cidre-Aranaz· 1 shared F. Klauschen· 1 shared I. Piseddu· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Kuenkele

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1 paper

Recent·Most cited

Cancer BiologybioRxivJan 5, 2022

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

T. L. B. Hoelting, F. Cidre-Aranaz, D. Matzek…·M. M. L. Knott

This paper develops a gene expression strategy that exploits neomorphic DNA-binding of fusion transcription factors in pediatric sarcomas to deliver therapeutic payloads with tumor-specific efficacy.

DOI 10.1186/s12943-022-01641-6

humanCRISPR screen