A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability
J. B. A. Sadler, D. M. Wenzel, L. K. Williams, M. Guindo-Martinez, S. L. Alam, J. M. Mercader, D. Torrents, K. S. Ullman, W. I. Sundquist, J. Martin-Serrano
This paper identifies a cancer-associated polymorphism in CHMP4C that disrupts the abscission checkpoint, leading to genome instability and increased cancer risk.
bioRxiv · Jul 3, 2018Cell Biology