In vitro effects of S-Licarbazepine as a potential precision therapy on SCN8A variants causing neuropsychiatric disorders
E. Bayraktar, Y. Liu, U. B. S. Hedrich, Y. Sara, H. Lerche, T. V. Wuttke, S. Lauxmann
This paper investigates the effects of S-Licarbazepine on SCN8A variants in neuroblastoma cells, showing variant-specific modulation of NaV1.6 channel biophysical properties.
bioRxiv · Apr 24, 2021Pharmacology & Toxicology