CD45 limits Natural Killer cell development from common lymphoid progenitors
L. G. Meza Guzman, C. D. Hyland, G. M. Bidgood, E. Leong, Z. Shen, W. Goh, T. Kratina, J. Rautela, J. Vince, S. Nicholson, N. Huntington
This study shows that CD45 deficiency in common lymphoid progenitors causes NK cell developmental defects, not enhanced persistence, suggesting CD45 inhibition could improve in vitro NK cell generation for therapy.
bioRxiv · Apr 17, 2023 · PreprintCell Biology