DNA replication stress induced by trifluridine determines tumor cell fate according to p53 status
Y. Kataoka, M. Iimori, R. Fujisawa, T. Morikawa-Ichinose, S. Niimi, T. Wakasa, H. Saeki, E. Oki, D. Miura, T. Tsurimoto, Y. Maehara, H. Kitao
This paper shows that trifluridine induces DNA replication stress that leads to different cell fates in tumor cells depending on their p53 status.
bioRxiv · Sep 13, 2019Cancer Biology