Cell BiologybioRxiv
Hematopoietic stem cells fail to regenerate following inflammatory challenge.
R. Bogeska, P. Kaschutnig, M. Fawaz…·M. D. Milsom
This study shows that repeated inflammatory challenges lead to progressive depletion of functional HSCs with no recovery, contributing to age-related hematopoietic decline.
DOI 10.1016/j.stem.2022.06.012