Non-canonical induction of autophagy increases adeno-associated virus type 2 (AAV2) transduction efficiency
S. O. Sutter, S. Jetzer, A. Lkharrazi, S. Pedersen, E. M. Schraner, B. Vogt, H. Büning, C. Fraefel
The paper shows that inducing autophagy with hyperosmotic sucrose enhances AAV2 transduction efficiency through a non-canonical pathway, distinct from the PI3K-III-dependent mechanism.
bioRxiv · Jan 8, 2024 · PreprintMicrobiology