mTORC1 controls phase-separation and the biophysical properties of the cytoplasm by tuning crowding
M. Delarue, G. P. Brittingham, S. Pfeffer, I. Surovtsev, K. J. Kennedy, S. Pinglay, J. I. Gutierrez, M. Schaffer, J. K. Chung, J. Plitzko, J. T. Groves, C. Jacobs-Wagner, B. D. Engel, L. J. Holt
The paper investigates how mTORC1 regulates macromolecular crowding and biophysical properties of the cytoplasm by using GEMs to measure diffusion and phase-separation changes.
bioRxiv · Dec 29, 2017Cell Biology