Human iPSC-Derived Cardiomyocytes Maladaptively Remodel to Cyclic Stretch in Hypoplastic Left Heart Syndrome
Riya Singh Verma, Ivy Zhang, Xunyang Chen, Maddison S Pierce, S. Ram Kumar, Megan Laura McCain
This study compares how HLHS patient-derived iPSC-CMs and control iPSC-CMs respond to cyclic stretch, finding impaired mechanoadaptation and heightened inflammation in HLHS cells.
bioRxiv · Oct 17, 2026 · PreprintPhysiology