Tumor Necrosis Factor induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit
F. Roca, S. Redmond, L. Ramakrishnan
This study shows that TNF induces macrophage necrosis in tuberculosis via a mitochondrial-lysosomal-endoplasmic reticulum circuit involving ROS, ceramide, and calcium overload.
bioRxiv · Jan 3, 2019Cell Biology