BiochemistrybioRxiv
ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
S. Aykul, L. Huang, L. Wang…·S. J. Hatsell
This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.
DOI 10.1172/jci153792