A. J. Murphy

Exploiting Embryonic Niche Conditions to Grow Wilms Tumor Blastema in Culture

This study develops a culture system to propagate Wilms Tumor blastemal cells using conditions that support nephron progenitor cell growth, enabling drug screening for cancer stem cells.

Divergent roles for caspase-8 and MLKL in high-fat diet induced obesity and NAFLD in mice

This study investigates the distinct roles of caspase-8 and MLKL in high-fat diet-induced obesity and NAFLD in mice, showing that MLKL contributes to disease independently of inflammation.

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

This study identifies the role of phospholipid remodeling and PUFA uptake via CD36 in megakaryopoiesis and platelet production, showing dietary fatty acids impact platelet counts.

An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

The paper characterizes immune cell lipidomes and shows how lipid composition influences susceptibility to ferroptosis.

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.

Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state

This study shows neuroblastoma cells can switch between a neuronal gene expression state and a de-differentiated state, with CD49b marking proliferative immature cells and CD49b-negative cells capable of generating tumors.

Structural insights into the assembly of gp130 family cytokine signaling complexes

The paper determines cryo-EM structures of gp130 family cytokine signaling complexes to reveal structural insights into their assembly and biological specificity.

Extracellular vesicles carrying HIV-1 Nef induce trained immunity in myeloid cells

The paper shows that HIV-1 Nef-containing extracellular vesicles induce trained immunity in myeloid cells through epigenetic changes and lipid raft upregulation, leading to persistent inflammation.

Inherent evolutionary unpredictability in cancer model system

This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.

Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

This study identifies XPO1 inhibition with selinexor as a potential therapy for favorable histology Wilms tumors, showing synergy with doxorubicin in preclinical models.

ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.

REGEN-COV protects against viral escape in preclinical and human studies

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters

This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.

The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

Targeted delivery of acid alpha-glucosidase corrects skeletal muscle phenotypes in Pompe disease mice

This study demonstrates that targeted enzyme replacement therapy using antibody-enzyme fusion proteins improves skeletal muscle phenotypes in Pompe disease mice compared to standard enzyme replacement therapy.