L. Wang

A generative reference grammar of healthy TCR repertoires reveals cancer-associated immune remodeling

CRAFT, a transformer model, learns a generative grammar of healthy TCR repertoires to detect cancer-associated immune remodeling through structured deviations in sequence space.

Enteroviral epitope mimicry enables NK cell-mediated targeting of ASPH in hepatocellular carcinoma

The paper identifies anti-CE1 antibodies that reduce HCC incidence and mortality by mediating NK cell ADCC against ASPH-expressing tumor cells through epitope mimicry.

Haplotype-resolved genome assembly advances genetic understanding of trait diversity in Phalaenopsis orchids

This study presents a haplotype-resolved genome for Phalaenopsis orchids, revealing genetic factors underlying trait diversity such as lip morphology and color patterns.

DNA-templated Chiral Metamaterial Array as Information Bits

This paper develops a DNA-templated chiral metamaterial array for secure optical information storage using plasmonic chirality to encode binary data.

CRISPR-Cas9-induced genetic mosaicism in three species of the microcrustacean Daphnia

This study evaluates genetic mosaicism in Daphnia species after CRISPR-Cas9 gene editing, finding mosaicism in 9 out of 11 targeted genes.

Structural Basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex

This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.

Metabolomics profiling reveals association of fermented herbal feed additive, growth performance and gut microbiota in piglets

This study shows that fermented Chinese medicine (FCM) improves piglet growth and health by increasing lactic acid and propionic acid levels and altering gut microbiota composition.

The neonatal Fc receptor and DPP4 are human astrovirus receptors

This study identifies FcRn and DPP4 as human astrovirus receptors and shows that targeting these factors with existing inhibitors prevents infection in human enteroid cultures.

Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice

This study compares the effects of moderate and vigorous exercise on intestinal damage, stress response, inflammation, and gut microbiota in mice, finding that daily moderate exercise causes more severe injury than vigorous training with rest days.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

A new yeast-based bioreporter for simple, sensitive, and cost-effective detection of dioxin-like compounds

This study develops a yeast-based bioreporter, DnaSc, for sensitive and cost-effective detection of dioxin-like compounds and AhR agonists with a detection limit of 10 fM for TCDD.

Native mass spectrometry of membrane protein-lipid interactions in different detergent environments

This study uses native mass spectrometry to investigate how different detergents and charge-reducing molecules affect protein-lipid interactions in membrane proteins.

The O-Fucosyltransferase SPINDLY Attenuates Auxin-Induced Fruit Growth by Inhibiting ARF6 and ARF8 binding to Coactivator Mediator Complex in Arabidopsis

This study shows that SPINDLY-mediated O-fucosylation of ARF6 and ARF8 inhibits their interaction with the coactivator Mediator complex, reducing fruit growth in Arabidopsis.

Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression in vitro and invivo

This study develops nanoparticles that co-deliver siRNA and mRNA to simultaneously silence and restore gene/protein expression in vitro and in vivo.

Marseilleviruses biological properties and viral translation-associated proteins based on in silico tertiary structure

This study reports four new marseillevirus strains, analyzes their biological properties, and predicts novel translation-associated proteins through in silico methods.

O-Glycosylated RNA Identification and Site-specific Prediction by Solid-phase Chemoenzymatic TnORNA method and PONglyRNA tool

This paper identifies and predicts O-glycosylated RNA using a chemoenzymatic method and a computational tool, revealing their role in pancreatic cancer progression.

The comparison of single-cell RNA sequencing platforms based droplets

This study compares droplet-based single-cell sequencing platforms to help researchers select the most suitable one for their applications.

B4 Raf-like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO-UBIQUITINATION 2

This study identifies RAF24 as a regulator of Arabidopsis flowering time through its effect on HUB2 phosphorylation and ubiquitin ligase activity.

Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton

The paper identifies a newly evolved TALE, Tal7b, that activates multiple GhSWEET genes in cotton, contributing to bacterial blight susceptibility.

An organoid platform reveals MEK-PARP co-targeting to enhance radiation response in rectal cancer

The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.

Sympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction

This study investigates sympathetic remodeling in rabbit hearts after reperfused myocardial infarction, finding CSPGs correlate with reduced nerve density but preserved sympathetic responsiveness, leading to increased arrhythmia risk.

Benzylic Trifluoromethyl Accelerates 1,6-Elimination Toward Rapid Probe Activation

This paper introduces a fluorescent probe that rapidly detects hydrogen sulfide in live cells through a benzylic trifluoromethyl group-enhanced 1,6-elimination reaction.

Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

This study uses snRNA-seq in pigs to reveal CLAs promote fat infiltration by altering myofiber types and adipocyte differentiation through JNK pathway inhibition.

Parallel Analyses by Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) Reveal Complementary Proteomic Profiles in Triple-Negative Breast Cancer (TNBC) Patient Tissues and Cell Cultures

The paper compares Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) in TNBC samples to assess their performance and identify complementary proteomic profiles.

Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 Diabetes Mellitus Rats

This study shows that Grifola frondosa polysaccharide reduces inflammation and insulin resistance in T2DM rats by modulating liver macrophage polarization.

ATTRv-V30M Type A amyloid fibrils from the heart and nerves exhibit structural homogeneity.

This study determines the structure of ATTRv-V30M amyloid fibrils from cardiac and nerve tissues using cryo-EM, finding structural homogeneity across tissues when transthyretin originates from the liver.

Detection of ATTR aggregates in plasma of polyneuropathic ATTR-V30M amyloidosis patients

The paper detects ATTR aggregates in plasma of polyneuropathic ATTR-V30M amyloidosis patients using a peptide probe and finds no correlation with age or gender.

Chloroquine Up-regulates Expression of SARS-CoV-2 receptor Angiotensin Converting Enzyme-2 in Endothelial Cells

This study shows chloroquine increases ACE2 expression in endothelial cells, potentially worsening SARS-CoV-2 infection in patients with cardiovascular or kidney diseases.

Gradual labeling with fluorogenic probes for MINFLUX nanoscopy of densely packed structures

This paper introduces GLF-MINFLUX, a method for nanoscale imaging of densely packed structures, achieving improved localization precision and faster acquisition.