A Chalcone Synthase-Like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells
E. E. Gulsan, F. Nowshad, M. D. Leigh, J. W. Cross, S. Safe, A. Jayaraman, K. Lee
The paper identifies a bacterial enzyme that cleaves naringenin, altering its bioactivity against nuclear receptors in intestinal cells, and shows how gut microbiota influence flavonoid metabolism and inflammation.
bioRxiv · Apr 22, 2022Microbiology