K. Lee

Studies of infused megakaryocytes into mice support a ''catch-and release'' model of pulmonary-centric thrombopoiesis

The paper shows that megakaryocytes are entrapped in the lungs, release cytoplasmic fragments, and undergo platelet formation, supporting a pulmonary-centric 'catch-and-release' model of thrombopoiesis.

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

Stem cell models of TAFAZZIN deficiency reveal novel tissue-specific pathologies in Barth Syndrome

This study uses stem cell models to investigate tissue-specific pathologies in Barth Syndrome caused by TAFAZZIN deficiency, identifying mitophagy defects and potential therapeutic targets.

The effect of enriched versus inadequate housing conditions on eucalyptus smoke-induced cardiovascular dysfunction in mice

This study shows that enriched housing improves cardiopulmonary resilience to wildfire smoke in mice compared to depleted housing.

Multiplex Imaging Reveals Novel Subcellular, Microenvironmental, and Racial Patterns of MRTFA/B Activation in Invasive Breast Cancers and Metastases

The paper uses multiplex imaging and bioinformatics to show distinct MRTFA/B activation patterns in breast cancer subtypes and racial disparities in MRTFA expression.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model

This paper develops a semi-automated cell tracking protocol to quantify neutrophil swarming in a mouse femur model with and without S. aureus infection, showing increased speed, displacement, and directionality in infected mice.

Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential

This study improves landomycin production in Streptomyces cyanogenus using spectrophotometric methods and characterizes their antimicrobial and anticancer activities.

The role of positively charged small biomolecules in the aggregation of hyperphosphorylated tau in Alzheimer's disease

This study identifies electrostatic interactions between hyperphosphorylated tau and polyamines as crucial for tau aggregation in Alzheimer's disease and observes the transition from aggregates to fibrils.

Positive Transfer of the Whisper Speech Transformer to Human and Animal Voice Activity Detection

This paper uses a pre-trained speech transformer for voice activity detection in both human and animal audio, improving accuracy with longer context and generalizing to new species.

Benchmarking nearest neighbor retrieval of zebra finch vocalizations across development

This study benchmarks nearest neighbor retrieval for zebra finch vocalizations, finding high performance in adults but lower in juveniles, with improved results using fixed-size templates and Spearman distance.

Evaluating steroid hormone receptor interactions using the live-cell NanoBRET proximity assay

This study uses a NanoBRET assay to evaluate hormone receptor interactions, finding that the ER Y537S mutation enhances ER/PR crosstalk beyond constitutive activity.

Cryogenic Soft Landing Improves Structural Preservation of Protein Complexes

This paper introduces a cryogenic landing system that improves structural preservation of protein complexes for cryo-electron microscopy.

Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure

This study examines the distribution and metabolomic effects of PCB 52 in female rats after intraperitoneal exposure, finding metabolites in serum and liver with minor changes in serum metabolites.

Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation

This paper develops APB-R3, a long-acting IL-18 blocker, showing efficacy in reducing inflammation in macrophage activation syndrome and atopic dermatitis models.

A Chemical Reaction Similarity-Based Prediction Algorithm Identifies the Multiple Taxa Required to Catalyze an Entire Metabolic Pathway of Dietary Flavonoids

The paper predicts and validates bacterial taxa capable of catalyzing the entire metabolic pathway of the flavonoid tilianin using a chemical reaction similarity-based algorithm.

Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

This study shows that oral administration of indole-3-acetate reduces liver steatosis and inflammation in mice fed a high-fat diet.

STORM imaging buffer with refractive index matched to standard immersion oil

This paper introduces a STORM imaging buffer with refractive index matched to standard immersion oil, improving imaging depth and resolution for thick tissues.

Genetic control of cell layer interactions in plants via tissue mechanics

The paper shows that brassinosteroid genes control tissue growth coordination in plants by modulating mechanical constraints between cell layers.

HIV viral protein R induces loss of DCT1-type renal tubules

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

This study shows that AA132, a compound with a 2-amino-p-cresol substructure, globally activates all three UPR arms by covalently modifying ER PDIs, while AA147 selectively activates the ATF6 arm.

Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence

This study shows that Listeria monocytogenes uses DHNA-dependent redox homeostasis via Ndh2 for survival and virulence, independent of respiration.

Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

This study shows that Leptospermum extract (QV0) reduces pleural mesothelioma tumour growth in vitro and in vivo by inducing mitochondrial dysfunction and apoptosis without adverse effects.

CD244 regulates both innate and adaptive immune axes in melanoma by inhibiting autophagy-mediated M1 macrophage maturation

This study shows CD244 inhibits macrophage maturation in melanoma, enhancing T cell responses and improving tumor rejection when combined with PD-L1 blockade.

Redox control and substrate specificity of the glycogen catabolic isoenzymes in Synechocystis sp. PCC 6803

This study investigates redox regulation and substrate specificity of glycogen catabolic isoenzymes in Synechocystis sp. PCC 6803, revealing redox control of GlgP1 and functional differences between GlgX1 and GlgX2.

Survivin is a mechanosensitive cell cycle regulator in vascular smooth muscle cells

The paper identifies survivin as a mechanosensitive regulator of cell cycle progression in vascular smooth muscle cells under mechanical stress.

Survivin Regulates Intracellular Stiffness and Extracellular Matrix Production in Vascular Smooth Muscle Cells

This study shows survivin regulates intracellular stiffness and ECM production in VSMCs, linking it to arterial stiffness and vascular disease.

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects in an in vivo murine model: Therapeutic implications

This paper shows that RUNX1-deficient human megakaryocytes have thrombopoietic and platelet defects in mice, which can be reversed by a TGFβ inhibitor.

Topical GZ21T inhibits the growth of actinic keratoses in a UVB induced model of skin carcinogenesis

This study evaluates a topical formulation of GZ17-6.02 (GZ21T) in a murine model of actinic keratoses, showing reduced lesion count and surface area, and prevention of progression to squamous cell carcinoma.

High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny

The paper uses nanopore sequencing to analyze repeat regions in T. pallidum genes, revealing clade-specific patterns that align with whole genome phylogeny.