Author

S. Vaena

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. A. de Cubas· 1 shared B. Granger· 1 shared E. Allen· 1 shared L. M. R. Ferreira· 1 shared M. J. Romeo· 1 shared R. A. Robino· 1 shared R. W. Cochrane· 1 shared S. Berto· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

A. A. de Cubas

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1 paper

Recent·Most cited

High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells

R. W. Cochrane, R. A. Robino, B. Granger, E. Allen, S. Vaena, M. J. Romeo, A. A. de Cubas, S. Berto, L. M. R. Ferreira

This study shows that high-affinity CAR signaling in human Tregs leads to increased cytotoxicity and inflammatory cytokine production, while lower affinity reduces these effects.

bioRxiv · Mar 31, 2024Immunology