High affinity interactions of Pb2+ with Synaptotagmin I
S. Katti, B. Her, A. K. Srivastava, A. B. Taylor, S. W. Lockless, T. I. Igumenova
This study identifies two high-affinity Pb2+ binding sites in Synaptotagmin I and shows Pb2+ can act as a kinetic and thermodynamic trap, interfering with Ca2+-dependent function.
bioRxiv · Jun 16, 2018Biophysics