Author

Sachdev S. Sidhu

Department of Pharmacy University of Waterloo Kitchener CanadaPrimary ORCID profile (0000-0001-7755-5918 · 9 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Sachdev S. SidhuiD9 papers · University of Toronto

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adam J. MiddletoniD· 1 shared Alexandre Orthwein· 1 shared Amélie Fradet-Turcotte· 1 shared Andreas Ernst· 1 shared Andrew Vorobyov· 1 shared Catherine L. DayiD· 1 shared Daniel DurocheriD· 1 shared Frank Sicheri· 1 shared

Activity by Year

2016-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Adam J. MiddletonORCID

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Author profile →

2 papers

Recent·Most cited

Structural and biophysical characterisation of ubiquitin variants that specifically inhibit the ubiquitin conjugating enzyme Ube2d2

Jeffery M. R. B. McAlpine, Jingyi Zhu, Nicholas Pudjihartono, Joan Teyra, Michael J. Currie, Zachary D. Tillett, Renwick C. J. Dobson, Sachdev S. Sidhu, Catherine L. Day, Adam J. Middleton

The paper identifies ubiquitin variants that inhibit Ube2d2, showing structural and biophysical properties that suggest potential for developing selective E2 enzyme inhibitors.

bioRxiv · Mar 10, 2024Biochemistry

A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing

Marella D. Canny, Leo C.K. Wan, Amélie Fradet-Turcotte, Alexandre Orthwein, Nathalie Moatti, Yu-Chi Juang, Wei Zhang, Sylvie M. Noordermeer, Marcus D. Wilson, Andrew Vorobyov, Meagan Munro, Andreas Ernst, Michal Zimmermann, Timothy F. Ng, Sachdev S. Sidhu, , Daniel Durocher

This paper develops a genetically encoded inhibitor of 53BP1, i53, which enhances homology-based gene editing by blocking NHEJ and promoting HR in non-replicating cells.

bioRxiv · Jun 28, 2016 · PreprintMolecular Biology