Wei Zhang

Genome-wide Analysis of the VQ Gene Family and Expression Profiling in Sorghum bicolor

This study identifies and characterizes VQ genes in sorghum, showing their differential expression and potential roles in salt stress tolerance.

Matrix-Mechanical Genetic Susceptibility and Reduced Inflammatory and Immediate-Early Programs in Keratoconus

This study identifies genetic susceptibility in keratoconus linked to extracellular matrix mechanisms and shows reduced inflammatory and immediate-early gene expression in corneal tissue.

Deciphering the gene-centric spatial dynamics across tissue and time with GeneSPOT

GeneSPOT is a gene-centric framework that characterizes spatial gene relationships and their reorganization across biological conditions and time.

NSD2 deficiency disrupts the epigenetic landscape of cochlear hair cells to enhance ECM expression and to perturb cochlear hair cell function

This study shows that NSD2 deficiency disrupts chromatin accessibility and gene expression in cochlear hair cells, leading to increased ECM expression and hearing impairment, which can be mitigated by ECM intervention.

Performance of a Modular Robotic Cluster Matches Skilled Human Operators for Complex Cell Therapy Manufacturing Tasks

A modular robotic system performs key unit operations in cell therapy manufacturing with accuracy comparable to human operators while ensuring throughput and flexibility.

Genome Assembly of the Green Revolution Wheat Cultivar Pavon 76 Establishes a Reference for CIMMYT-Derived Wheat

The paper assembles the genome of Pavon 76, a Green Revolution wheat cultivar, providing a chromosome-scale reference for CIMMYT-derived wheat and highlighting structural divergence from the standard reference genome.

Chronic Mild Stress Impairs Hippocampal Myelination through SOX6-Dependent Dysfunction of Oligodendrocyte Lineage Cells

This study identifies SOX6 as a key regulator of oligodendrocyte dysfunction under chronic stress, linking stress to myelination deficits through molecular mechanisms.

Robust lesion network mapping reveals symptom-specific circuits

This paper introduces robust lesion network mapping (rLNM) to address statistical validity concerns in lesion network mapping, showing it recovers distinct symptom-specific networks and predicts postoperative language decline.

Cell-type-resolved RNP topologies reveal dynamic structural mechanisms of splicing and therapeutic targets

The paper introduces SHARCLIP to map RNA-RNA, RNA-protein, and protein-protein contacts in cells, revealing structural mechanisms of splicing and therapeutic targets.

A regulatory role of novel long non-coding RNA, BAZ1A-AS1, in vascular smooth muscle cell functions during neointima formation in human saphenous veins

DCN1 inhibitor induces fetal hemoglobin through self-limited regulation of CUL3 neddylation

The paper identifies DCN1 as a therapeutic target for beta-hemoglobinopathies by showing its inhibition increases fetal hemoglobin through selective chromatin changes without cytotoxicity.

Interactive Effects of Biological Maturation and Relative Age Effect on Talent Identification for U16 Elite Soccer Players

This study examines how biological maturation and relative age effect influence talent identification in U16 elite soccer players, finding significant impacts of maturation on physical and performance metrics but not on selection criteria.

Impact of Enteric Neuronal Loss on Intestinal Cell Composition

This study investigates how loss of the enteric nervous system in zebrafish affects intestinal cell composition and identifies similar changes in human HSCR tissues.

MetaReact: A Reaction-Aware Transformer for End-to-End Prediction of Drug Metabolism

MetaReact predicts drug metabolites and enzyme selectivity using a reaction-aware Transformer, outperforming existing methods in accuracy and generalizability.

Distinct Chiral Nanostructures of Graphene Quantum Dots Govern Divergent Passive and Active Enantioselective Transport across Biological Membranes

This study investigates how chiral ligand modulated graphene quantum dots (GQDs) form distinct nanostructures that influence passive and active enantioselective transport across biological membranes.

PRDM1 Drives Chemoradiotherapy-associated Enrichment of Adaptive NK Cells in Cervical Cancer

This study identifies PRDM1 as a key regulator of adaptive NK cell enrichment and functional activation in cervical cancer following chemoradiotherapy.

Riboflavin Deficiency-Induced Angular Stomatitis and Conjunctivitis in Associated with Gut Microbiota Dysbiosis

This study shows riboflavin deficiency in rats causes ariboflavinosis with angular stomatitis and conjunctivitis, linked to gut microbiota dysbiosis and altered glycan metabolism.

Lactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

This study shows that Lactiplantibacillus plantarum PS128 improves autism-like behaviors in Fmr1 knockout mice by restoring gut microbiota-driven polyamine homeostasis.

Gliomas preferentially develop within the action-mode network

This study identifies a functionally connected glioma network overlapping with the action-mode network and shows its prognostic significance and association with acetylcholine transporter expression.

Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae: Risk factors and resistance mechanism of ceftazidime/avibactam in China

This study analyzes carbapenem-resistant hypervirulent Klebsiella pneumoniae strains in China, identifying resistance mechanisms and risk factors for ceftazidime/avibactam.

Tryptophan Chemistry Driven by a Widespread Cytochrome P422 Enzyme Family

The paper identifies a widespread cytochrome P422 enzyme family that performs four novel tryptophan transformations, revealing new enzymatic capabilities and introducing a computational tool for HBP discovery.

Rapid ecosystem collapse and biofilter formation following seabed methane leakage

This study shows that seabed ecosystems rapidly collapse and form a methane biofilter after methane leakage from hydrates, with significant microbial and macrofaunal changes.

A regulator controls both DNA damage response and anti-phage defense networks in Moraxellaceae

This study identifies a WYL family protein in Moraxellaceae that regulates both DNA damage response and anti-phage defense networks, enhancing understanding of bacterial immunity and antibiotic resistance.

Specific Pathogen Free Ten Gene-Edited Pig Donor for Xenotransplantation

This study generates 10-gene-edited pigs that reduce immune rejection and zoonotic risks for xenotransplantation, showing improved survival in non-human primate recipients.

Nervous system-wide single-cell morphology atlas of excitatory and inhibitory neurons in larval zebrafish

The paper creates a comprehensive atlas of larval zebrafish neuron morphology, including excitatory and inhibitory identities and connectivity patterns.

Salt-inducible kinase inhibition promotes weight loss and improves the diastolic function of obesity-related heart failure with preserved ejection fraction in mice

This study shows that inhibiting salt-inducible kinases (SIKs) reduces weight gain and improves diastolic heart function in obese mice with heart failure with preserved ejection fraction (HFpEF).

Characterization of bronchiolitis and vaccine-induced enhanced respiratory disease in Syrian hamsters caused by respiratory syncytial virus infection

This study characterizes RSV infection and vaccine-induced ERD in Syrian hamsters, showing age-dependent viral replication, pathological changes, and ERD responses similar to humans.

Deep learning-based Spatial Feature Extraction for Prognostic Prediction of Hepatocellular Carcinoma from Pathological Images

This study develops a deep learning method to extract spatial features from H&E images of HCC, identifying features associated with patient survival and improving prognostic stratification when combined with clinical features.

Molecular signatures associated with successful implantation of the human blastocyst

The paper identifies molecular signatures in human blastocysts associated with successful implantation by analyzing gene expression and cell-cell interactions in embryos with different morphological grades.

Dissecting the Genetic Basis of Superior Traits in Thermosensitive Genic Male Sterile Line 1892S Through Genome-Wide Analysis

This study identifies superior alleles in the thermosensitive genic male sterile rice line 1892S through genome-wide analysis, revealing genetic factors contributing to its adaptability and hybrid vigor.