dubTAGs enable on-demand stabilization for tunable and reversible control of endogenous protein levels
Sunil Guharajan, Xiangyang Song, Sachi Sengupta, Qiong Wu, Wenyi Wei, Yan Xiong, Jian Jin, Sahin Naqvi
The paper introduces dubTAGs, small molecules that stabilize proteins tagged with FKBP12F36V by recruiting deubiquitinases, enabling tunable and reversible control of protein levels.
bioRxiv · Sep 18, 2026 · PreprintMolecular Biology