Sam Cooper

Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy.

This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.

Bigh3 is essential for pulmonary fibrosis

This study shows Bigh3 is essential for lung fibrosis by demonstrating its role in fibroblast-macrophage interactions and collagen expression.

Adversarial learning enables unbiased organism-wide cross-species alignment of single-cell RNA data at scale

This paper introduces a method to align single-cell RNA data across species and tissues using adversarial learning, revealing common cell types like macrophages and fibroblasts.

scMARK an 'MNIST' like benchmark to evaluate and optimize models for unifying scRNA data

The paper introduces scMARK, a benchmark dataset and framework to evaluate scRNA integration tools, finding that scVI is the only tool tested capable of integrating scRNA studies at scale.

Learning unsupervised feature representations for single cell microscopy images with paired cell inpainting

This paper introduces a self-supervised CNN method to learn high-quality features for single-cell microscopy images without labeled data, showing improved performance in protein localization and analysis.