Author
The Francis Crick InstituteORCID 0000-0001-9154-3526Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Anna Clare Wilkins, Spyridon Makris, Mary J. Green…·Erik A. Sahai
This study shows that radiation-induced podoplanin-positive fibroblasts limit CD8+ T-cell access to tumour cells, reducing radiotherapy effectiveness, and that disrupting PDPN signaling enhances tumour control.
Sandra Segura‐Bayona, Valérie Borel, Tyler H. Stanage…·Simon J. Boulton
This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.
Imran Noorani, Magnus J. Haughey, Jens Luebeck…·Benjamin Werner
This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.
Piyali Ganguli, Celia De Los Angeles Colomina Basanta, Amelia Acha‐Sagredo…·Jo Spencer
The paper investigates how CDKN2A and other 9p21 gene losses influence oesophageal cancer progression, finding context-dependent effects on survival and immune infiltration.
David Carreño, Clare M. Robinson, Raphaella Jackson…·David T. Riglar
The paper uses engineered bacterial biosensors to measure sialic acid availability in the inflamed mouse gut, revealing spatial and temporal variations linked to inflammation.
Borzo Gharibi, Emanuel Gonçalves, Buhe Nashun…·Silvia D. M. Santos
This study identifies an FGF2-mediated incoherent feedforward loop that inhibits Erk and promotes naive pluripotency in ES cells and embryos.