Whole genome analysis for 163 guide RNAs in Cas9 edited mice reveals minimal off-target activity
Kevin A. Peterson, Sam Khalouei, Nour Hanafi, Joshua A. Wood, Denise Grant Lanza, Lauri G. Lintott, Brandon Willis, John R. Seavitt, Robert E. Braun, Mary E. Dickinson, Jacqueline K. White, K. C. Kent Lloyd, Jason D. Heaney, Stephen A. Murray, Arun K Ramani, Lauryl M. J. Nutter
The paper analyzes whole-genome sequencing data from Cas9-edited mice to assess off-target mutagenesis, finding minimal off-target activity across 163 guide RNAs.
Communications Biology · Jun 10, 2023Peer-reviewedGenetics