Mitochondrial Double-Stranded RNA Triggers Ferroptosis via PKR-ISR Signaling in Renal Ischemia-Reperfusion Injury
Richie Justin, Maria Sophia Criste, Soyoung Park, Fedho Kusuma, Nara Lee, Yerin Yang, Kim Anh Nguyen, Samel Park, 김정안, Hyo‐Wook Gil, Jaeseok Han
This study identifies mitochondrial dsRNA-PKR-ISR signaling as a driver of ferroptosis in renal ischemia-reperfusion injury, showing that targeting this pathway reduces ferroptosis and preserves kidney function.
bioRxiv · Jan 20, 2026 · PreprintCell Biology