Preservation of dopamine neurotransmission during nigrostriatal neuron loss in rat Parkinson model: evidence for increased dopamine signaling in substantia nigra
Ashley Galfano, Robert McManus, Walter Navarrete, Sampada Chaudhari, Christopher Bishop, Michael F. Salvatore
The paper investigates compensatory mechanisms in dopamine signaling during nigrostriatal neuron loss in a rat Parkinson model, finding that dopamine levels are preserved in the substantia nigra despite significant TH loss.
bioRxiv · Sep 12, 2025 · PreprintNeuroscience