A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity
Alyssa Synan, Nila C. Wu, Roberto Velazquez, Thomas G. Gesner, Claude Logel, Kathrin Mueller, Andrew R. Green, Patrizia Barzaghi-Rinaudo, Quincey Simmons, Samuele Mercan, Xingyi Shi, Xun Li, Vivek Sagar, Joshua M. Korn, Margaret E. McLaughlin, , Joseph A. D’Alessio
This study develops a bispecific antibody-drug conjugate targeting pCAD and CDH17, showing antitumor activity in dual antigen-expressing tumors but not in single antigen-expressing tumors.
mAbs · Jan 6, 2025Peer-reviewedCancer Biology