Discovery of Membrane Channel Modulators via DNA-Encoded Library Screening Using Native-Like Membrane Protein Nanoparticles
Francesco V. Reddavide, Trine Lisberg Toft‐Bertelsen, Ieva Drulyte, Aspen Rene Gutgsell, Dzung Nguyen, Sara Bonetti, Katerina Vafia, Anne-Sophie Tournillon, Stephan Heiden, Daniel Grosser, Katarina Iric, Veronica Diez, Nanna MacAulay, Stefan Geschwindner, Michael Thompson, , Robin Löving
This paper develops a method to discover PANX1 modulators using DNA-encoded library screening with stabilized membrane protein nanoparticles and validates hits through biophysical and electrophysiological assays.
Scientific Reports · Jun 15, 2026Peer-reviewedBiochemistry