Stefan Geschwindner

This paper develops a method to discover PANX1 modulators using DNA-encoded library screening with stabilized membrane protein nanoparticles and validates hits through biophysical and electrophysiological assays.

The paper studies how dynamic conformational changes in pre-miR-377's Dicer site enable small-molecule recognition, showing that binding depends on RNA dynamics rather than a single structure.

The paper evaluates the impact of PROTAC valency on hook effects, showing that trivalent PROTACs do not eliminate the hook effect but may alter its dynamics.

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.