Autophagy activator AA-20 engages CDK5 to promote lipophagy and improve neurodegeneration-associated phenotypes
Ee Phie Tan, Lydia Ambaye, Anne-Laure Mahul-Mellier, Yuting Zhang, Patricia Martinez-Botia, Sergio R. Labra, Lynee A. Massey, Zi Gao, Zainab Ahmed, Karina Nugroho, Carl Ash, Wen Ren, Christian M. Cole, Yin Wu, Sarah Ly, , Jeffery W. Kelly
AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.
bioRxiv · Nov 2, 2026 · PreprintMolecular Biology