Fertilization offsets the maternal age effect on mouse oocytes provided the oviduct is not itself aged
Michele Boiani, Thomas Nolte, Julina Wiese, Georg Fuellen, Annalen Buechsenschuetz, Saskia Winter, Hannes C.A. Drexler
This study shows that fertilization can reverse the negative effects of maternal age on oocyte quality in mice, provided the fertilization environment is not aged.
bioRxiv · Nov 2, 2026 · PreprintDevelopmental Biology