Author

Sazzad Khan

University of Tennessee Health Science Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Jianfeng XiaoiD· 3 shared Mohammad Moshahid KhaniD· 3 shared Daniel Johnson· 2 shared Himanshi SinghiD· 2 shared Asmita DasiD· 1 shared Daniel L. JohnsoniD· 1 shared Francesca Fang-Liao· 1 shared Jasim KhaniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Jianfeng XiaoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

DYT1 mutation alters gut microbiome composition and gut-brain axis dynamics in a mouse model

Jianfeng Xiao, Sazzad Khan, Pradeep K. Shukla, Daniel Johnson, Mohammad Moshahid Khan

This study shows that DYT1 mutations in mice disrupt gut microbiome composition and gut-brain axis dynamics, linking intestinal dysfunction to motor impairments.

bioRxiv · Dec 17, 2025 · PreprintNeuroscience

Arsenic Trioxide Underpins Delayed Neuroinflammation and Impaired Synaptic Integrity involving Integrative Stress Response Signaling

Jasim Khan, Sazzad Khan, Himanshi Singh, Jianfeng Xiao, Daniel Johnson, Mohammad Athar, Mohammad Moshahid Khan

This study identifies the integrated stress response (ISR) activation and DNA damage-driven immune dysregulation as key drivers of ATO-induced delayed neurotoxicity and cognitive deficits.

bioRxiv · Dec 2, 2025 · PreprintNeuroscience

Harnessing cGAS-STING signaling to counteract the genotoxic-immune nexus in tauopathy

Himanshi Singh, Sazzad Khan, Jianfeng Xiao, Nicole Nguyen, Asmita Das, Daniel L. Johnson, Francesca Fang-Liao, Sally Ann Frautschy, Michael P. McDonald, Tayebeh Pourmotabbed, Mohammad Moshahid Khan

This study identifies a cGAS-STING signaling loop driving neuroinflammation and tau pathology in tauopathies, showing its disruption can alleviate disease symptoms.

bioRxiv · Sep 27, 2025 · PreprintNeuroscience