Author

Sean Pascoe

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Aaron S. MeyeriD· 1 shared Andrew Ramirez· 1 shared Ann M. CariasiD· 1 shared Anne MonetteiD· 1 shared Armaan A. Abraham· 1 shared Breanna Remigio· 1 shared Brian T. Orcutt-JahnsiD· 1 shared Christopher T. Thuruthiyil· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperSystems Biology

Aaron S. MeyerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A Tissue Virus Microenvironment with Activated Stress Responses Underlies Durable SIV Persistence

Thomas J. Hope, Eliana U. Crentsil, Muhammad S. Arif, Yanique Thomas, Ellen Zhang, Christopher T. Thuruthiyil, Ryan V. Moriarty, Flora Engelmann, Sean Pascoe, Jenna M. Hasson, Seth H. Borrowman, Maryam A. Shaaban, Edward J. Allen, Anne Monette, Ann M. Carias, , Ramón Lorenzo-Redondo

This study identifies a tissue virus microenvironment with stress responses that supports SIV persistence, contrasting with transient reservoirs that show immune activity.

bioRxiv · Oct 15, 2026 · PreprintMicrobiology

Integrative, high-resolution analysis of single cell gene expression across experimental conditions with PARAFAC2-RISE

Andrew Ramirez, Brian T. Orcutt-Jahns, Sean Pascoe, Armaan A. Abraham, Breanna Remigio, Nathaniel Thomas, Aaron S. Meyer

RISE, an adaptation of PARAFAC2, enables dimensionality reduction and analysis of single-cell RNA-seq data across experimental conditions by separating condition-specific effects from cell-to-cell variation.

Cell Systems · May 15, 2025Peer-reviewedSystems Biology