Author

Sen Hong

Howard Hughes Medical InstitutePrimary ORCID profile (0000-0001-6545-8731 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Sen HongiD1 paper · Howard Hughes Medical Institute

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Helen H. HobbsiD· 2 shared Xiaochun LiiD· 2 shared Jin Wang· 1 shared Jonathan C. CoheniD· 1 shared Liangjie JiaiD· 1 shared Matthew A. MitscheiD· 1 shared Nadia Elghobashi‐MeinhardtiD· 1 shared Rong WangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Helen H. HobbsORCID

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2 papers

Recent·Most cited

TM6SF2 is a cholesterol-bound homomultimeric ER membrane protein that binds ApoB and is required for bulk lipidation of VLDL

Sen Hong, Jin Wang, Matthew A. Mitsche, Jonathan C. Cohen, Xiaochun Li, Helen H. Hobbs

This study determines the structure of TM6SF2 and shows its role in lipidation of ApoB-containing lipoproteins, with a variant affecting cholesterol binding and function.

bioRxiv · Sep 28, 2026 · PreprintCell Biology

Structure and Function of TM6SF1 Reveal Role in mTORC1 Signaling

Sen Hong, Liangjie Jia, Rong Wang, Nadia Elghobashi‐Meinhardt, Helen H. Hobbs, Xiaochun Li

This study determines the cryo-EM structure of TM6SF1 and shows it regulates mTORC1 signaling through cholesterol-dependent interaction with LAMTOR1, affecting TFEB activation.

Proceedings of the National Academy of Sciences · Sep 14, 2026Peer-reviewedCell Biology