Author

Seppo Koskinen

Finnish Institute for Health and Welfare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Research Focus:fine-mapping· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

George Davey SmithiD· 2 shared Priit PaltaiD· 2 shared Samuli RipattiiD· 2 shared Shane McCarthyiD· 2 shared Veikko V SalomaaiD· 2 shared Aarno Palotie· 1 shared Aarno V. PalotieiD· 1 shared Aaron Kleinman· 1 shared

Activity by Year

2016-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenetics

George Davey SmithORCID

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3 papers

Recent·Most cited

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

Padhraig Gormley, Mitja Kurki, Marjo Eveliina Hiekkala, Kumar Veerapen, Paavo Häppölä, Adele A. Mitchell, Dennis Lal, Priit Palta, Ida L. Surakka, Mari Anneli Kaunisto, Eija Hämäläinen, Salli Vepsäläinen, Hannele Havanka, Hanna Harno, Matti Ilmavirta, , George McMahon

This study shows common genetic variants significantly contribute to migraine family clustering, with higher burden in familial cases compared to population-based cases.

Neuron · May 1, 2018Peer-reviewedGenetics

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

Luke M. Evans, Rasool Tahmasbi, Matthew Jones, Scott I. Vrieze, Gonçalo R. Abecasis, Sayantan Das, Douglas W. Bjelland, Teresa R de Candia, David Altshuler, Carl A. Anderson, Andrea Angius, Jeffrey C. Barrett, Sonja I. Berndt, Michael Boehnke, Dorrett Boomsma, , George Davey Smith

This paper estimates narrow-sense heritability using identity-by-descent information in unrelated individuals and finds that IBD-based methods can capture rare variant contributions but are affected by stratification.

Heredity · Mar 28, 2018Peer-reviewedGenetics

Whole genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom

Himanshu Chheda, Priit Palta, Matti Pirinen, Shane McCarthy, Klaudia Walter, Seppo Koskinen, Veikko Salomaa, Mark Daly, Richard Durbin, Aarno Palotie, Tero Aittokallio, Samuli Ripatti

The paper compares genome sequences from Finnish and British populations to identify genetic variants enriched in a population bottleneck, finding significant enrichment of rare variants in Finns.

bioRxiv · Jul 12, 2016Genetics