Author

Adele A. Mitchell

Biogen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 2 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Research Focus:variant effect prediction· 3 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Heiko RunziD· 2 shared Aaron Day-Williams· 1 shared Aaron Kleinman· 1 shared Adam AutoniD· 1 shared Alex Bloemendal· 1 shared Alexander Wahl· 1 shared Alfons MacayaiD· 1 shared Ammar Al‐ChalabiiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetic & Genomic Medicine

Heiko RunzORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Landscapes of missense variant impact for human superoxide dismutase 1

Anna Axakova, M. Ding, Atina G. Coté, Radha Subramaniam, Vignesh Senguttuvan, Haotian Zhang, Jochen Weile, Samuel V. Douville, Marinella Gebbia, Ammar Al‐Chalabi, Alexander Wahl, Jason Reuter, Jessica A. Hurt, Adele A. Mitchell, Stephanie Fradette, , Frederick P. Roth

The paper measures the functional impact of over two thousand SOD1 missense variants using saturation mutagenesis and cell-based assays, reclassifying 41% of previously uncertain variants as pathogenic.

The American Journal of Human Genetics · Sep 16, 2025Peer-reviewedGenetics

Rare genetic variants impact muscle strength

Yunfeng Huang, Dóra Bodnár, Chia‐Yen Chen, Gabriela Sánchez-Andrade, Mark Sanderson, Biogen Biobank Team, Christopher D. Whelan, Paola G. Bronson, David Sexton, Sally John, Eric Marshall, Mehool Patel, Saranya Duraisamy, Timothy Swan, Denis A. Baird, , Heiko Runz

This study identifies six genes associated with hand grip strength using rare protein-coding variants in 340,319 individuals and shows additive effects with common variants.

Nature Communications · Jun 10, 2023Peer-reviewedGenetic & Genomic Medicine

Phenotype-specific information improves prediction of functional impact for noncoding variants

Corneliu Alexandru Bodea, Adele A. Mitchell, Alex Bloemendal, Aaron Day-Williams, Heiko Runz, Shamil R. Sunyaev

PINES improves noncoding variant functional impact prediction by integrating phenotype-dependent epigenetic annotations.

bioRxiv · May 3, 2018 · PreprintGenomics

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families

Padhraig Gormley, Mitja Kurki, Marjo Eveliina Hiekkala, Kumar Veerapen, Paavo Häppölä, Adele A. Mitchell, Dennis Lal, Priit Palta, Ida L. Surakka, Mari Anneli Kaunisto, Eija Hämäläinen, Salli Vepsäläinen, Hannele Havanka, Hanna Harno, Matti Ilmavirta, , George McMahon

This study shows common genetic variants significantly contribute to migraine family clustering, with higher burden in familial cases compared to population-based cases.

Neuron · May 1, 2018Peer-reviewedGenetics