Multi-level repression ensures tight translation control of C9ORF72
Solomon A. Haizel, Alfredo Vidal Ceballos, Alice Nayoung Ko, Lucas Lyu, Lauren Manning, Xinyi Ge, Violet Park, Huijing Zou, Churong Cheng, Richmond Afful, Serena Kher, Anissa Anindya Widjaja, Joanetta Jean-Baptiste, Sasha Khazhinsky, Pieter Spealman, , Christine Vogel
The paper investigates the multi-layered repression system controlling C9ORF72 translation and identifies strategies to rescue loss-of-function in disease.
bioRxiv · Aug 9, 2025 · PreprintMolecular Biology