Extracellular cGAMP transmission exacerbates neuroinflammation in aging and multiple sclerosis
Dayanne R. Carvalho, Rina Wang, Nuo Liu, Yu Li, Talal Younis, Alessandra Sclip, Seula Shin, April Pawluk, Christoph Thaiss, Christoph A. Thaiss, Silvana Konermann, Lingyin Li
This study shows that extracellular cGAMP worsens neuroinflammation in aging and MS by activating STING in microglia, astrocytes, and inhibitory neurons, with ENPP1 acting as a protective brake.
bioRxiv · Oct 3, 2026 · PreprintImmunology