Fatty acid desaturation guides cellular decisions between ferroptosis and cellular senescence
Chisaka Kuehnemann, Samantha T. Jezak, Bronwyn A. Mogck, Niharika Kura, Rushmeen Tariq, Yuheng Che, Maija Vaittinen, Ioannis Siokas, Sharvari Deshpande, Carlyn Guthrie, Xuejuan Tan, Eliézer Aïmontché, Aleksandra Aljakna Kahn, Peter Reifsnyder, Gung Lee, , Christopher D. Wiley
The paper shows that fatty acid desaturation, specifically DGLA, influences cellular decisions between ferroptosis and senescence, with implications for aging and obesity.
Cell · Nov 1, 2026Peer-reviewedCell Biology